Our 'Human Milk, Tailor-Made for Tiny Humans' advert. Click on 'CC' (bottom right of the video) for more languages.
is central to the lasting health of our species and of our planet. It is both an urgent public health and a climate justice issue, and the astonishing contents of human milk show us why.
The World Health Organisation recommends exclusive breastfeeding for 6 months, continued alongside other food and drinks until at least the child’s second birthday.
But an estimated 843,000 infants die globally each year because they are not being breastfed and protected by the components in human milk, alongside 20,000 women who would survive breast cancer.
Breastfeeding protects infants against all sorts of short term illnesses; colds, ear infections, lung infections, tummy bugs and more, but it also protects against longer term diseases like certain cancers, obesity, diabetes, eczema, malnutrition.
What’s less well known is that it also protects women. Breastfeeding reduces our risk of breast and ovarian cancers, heart disease, diabetes, weight gain, and postnatal depression for instance.
Women are passionate about breastfeeding with good reason.
Most mothers want to breastfeed, but many are interrupted by various social and environmental elements. The responsibility must not rest on individual mothers.
Knowledge of the science of human milk and breastfeeding is key to families, friends, healthcare professionals and the general public fully understanding why breastfeeding matters so much and to breastfeeding mothers being actively supported.
Mothers report to us that learning about their milk has deepened their confidence, their connection to themselves, to their baby, their body, their choice to breastfeed, and often to the people they rely on for support.
The composition of human milk can help us make sense of it all:
Dutch researchers find Covid-19 antibodies in human milk
‘We think when drinking the milk, the antibodies attach themselves to the surface of our mucous membranes,’ Hans van Goudoever, head of the Emma children’s hospital at the UMC, said. ‘Then they attack the virus particles
before they force their way into the body.’
Human milk contains stem cells. These are cells that create and repair the body, and are being researched worldwide to cure conditions like Alzheimers and diabetes.
The composition of human milk changes throughout the day, the night, the months and the years, to meet your child's needs.
The biologically normal age for humans to breastfeed until is anywhere between around 2 and 7+ years old. This is only surprising in cultures that tend to interrupt breastfeeding early, often having lost the knowledge of what our biological norms are, in favour of cultural norms.
“There is a widespread misconception that breastmilk can be replaced with artificial products without detrimental consequences and that the benefits of breastfeeding only relate to poor countries. Nothing could be further from the truth. The importance of tackling this global issue is greater now than ever before.”
Professor César Victora, Lancet Author, 2016
You can download all our educational materials free of charge on our Download Resources page.
Scroll down to see the research references.
Spread the word!
You can download all our education materials, including the advert, infographic, and more on our Education Resources page.
This is free of charge because we know that breastfeeding support is often under/un-funded, and we want everyone to have equitable access to our materials.
Purchases from our shop fuel this offer. Spread the word!
And thank you for helping us to make the science of human milk and breastfeeding common knowledge.
References
Research supporting the information in our advert, education, and social media content.
“Nature has been researching your milk for hundreds of millions of years”
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Capuco AV, Akers RM. The origin and evolution of lactation. J Biol. 2009; 8(4): 37.
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Oftedal OT. The mammary gland and its origin during synapsid evolution. J Mammary Gland Biol Neoplasia. 2002; 7(3): 225–52.
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Oftedal OT. The origin of lactation as a water source for parchment-shelled eggs. J Mammary Gland Biol Neoplasia. 2002; 7(3): 253-66.
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Oftedal OT, Dhouially D. Evo-Devo of the Mammary Gland. Journal of Mammary Gland Biology and Neoplasia. 2013; 18: 105-120.
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Capuco AV, Akers RM. The origin and evolution of lactation. Journal of Biology. 2009; 8(4): 37.
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Goldman AS. Evolution of the mammary gland defense system and the ontogeny of the immune system. J Mammary Gland Biol Neoplasia. 2002; 7: 277–289.
“Your milk contains ingredients that kill cancerous cells”
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Gustafsson L, Hallgren O, Mossberg AK, et al. HAMLET kills tumour cells by apoptosis: structure, cellular mechanisms, and therapy. J Nutr. 2005; 135: 1299-1303.
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Håkansson A, Zhivotovsky B, Orrenius S, Sabharwal H, Svanborg C. Apoptosis induced by a human milk protein. Proc Natl Acad Sci U S A. 1995; 92(17): 8064-8.
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Hallgren O, Aits S, Brest P, Gustafsson L, Mossberg AK, Wullt B, Svanborg C. Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells). Adv Exp Med Biol. 2008; 606: 217-40.
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Hakansson AP, Roche-Hakansson H, Mossberg AK, Svanborg C. Apoptosis-like death in bacteria induced by HAMLET, a human milk lipid-protein complex. PLoS One. 2011; 6(3): e17717.
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Kataev A, Zherelova O, Grishchenko V. A Characeae Cells Plasma Membrane as a Model for Selection of Bioactive Compounds and Drugs: Interaction of HAMLET-Like Complexes with Ion Channels of Chara corallina Cells Plasmalemma. J Membr Biol. 2016; 249(6): 801-811.
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Jiang R, Du X, Lönnerdal B. Comparison of bioactivities of talactoferrin and lactoferrins from human and bovine milk. J Pediatr Gastroenterol Nutr. 2014; 59(5): 642-52.
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Hill DR, Newburg DS. Clinical applications of bioactive milk components. Nutr Rev. 2015; 73(7): 463-76.
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Vogel HJ. Lactoferrin, a bird's eye view. Biochem Cell Biol. 2012; 90(3): 233-44.
“Your milk contains stem cells. These are cells that create and repair the body, and are being researched worldwide to cure conditions like Alzheimers and diabetes.”
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Cregan MD, Fan Y, Appelbee A, et al. Identification of nestin-positive putative mammary stem cells in human breastmilk. Cell Tissue Res. 2007; 329: 129-136.
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Hassiotou F, Beltran A, Chewynd E, et al. Breastmilk is a novel source of stem cells with multilineage differentiation potential. Stem Cells. 2012; 30(10): 2164-74.
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Briere CE, McGrath JM, Jensen T, Matson A, Finck C. Breast Milk Stem Cells: Current Science and Implications for Preterm Infants. Adv Neonatal Care. 2016; 16(6): 410-419.
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Twigger AJ, Hepworth AR, Lai CT, Chetwynd E, Stuebe AM, Blancafort P, Hartmann PE, Geddes DT, Kakulas F. Gene expression in breastmilk cells is associated with maternal and infant characteristics. Sci Rep. 2015; 5: 12933.
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Choi SS, Lee SR, Lee HJ. Neurorestorative Role of Stem Cells in Alzheimer's Disease: Astrocyte Involvement. Curr Alzheimer Res. 2016; 13(4): 419-27.
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Lilly MA, Davis MF, Fabie JE, Terhune EB, Gallicano GI. Current stem cell based therapies in diabetes. Am J Stem Cells. 2016; 5(3): 87-98.
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Cheng SK, Park EY, Pehar A, Rooney AC, Gallicano GI. Current progress of human trials using stem cell therapy as a treatment for diabetes mellitus. Am J Stem Cells. 2016; 5(3): 74-86.
“Your body identifies bacteria and viruses found in your baby's body and environment. You then produce antibodies specifically tailored for those infections, and deliver them to your baby through your milk. The more milk she drinks, the more antibodies she receives.”
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Donald K, Petersen C, Turvey SE, Finlay BB, and Azad MB. Secretory IgA: Linking microbes, maternal health, and infant health through human milk.
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Gopalakrishna KP, Macadangdang BR, Rogers MB, Tometich JT, Firek BA, Baker R, Ji J, Burr AHP, Ma C, Good M, Morowitz MJ, Hand TW. Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants.
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Goldman AS, Garza C, Nichols BL, Goldblum RM. Immunological factors in human milk during the first year of lactation. J Pediatr. 1982; 100; 563-567.
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Johnson-Hence C, Gopalakrishna PK, Bodkin D, Coffey KE, Burr AH, Rahman S, Rai AT, Abbott DA, Sosa YA, Tometich JT, Das J, Hand TW. Stability and heterogeneity in the anti-microbiota reactivity of human milk-derived Immunoglobulin A.
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Pickering LK, Kohl S. Human milk humoral immunity and infant defense mechanisms. In: Howell RR, Morriss FH, Pickering LK, eds. Human milk in infant nutrition and health. Springfield, IL: Thomas; 1986: 123-140.
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Litwin SD, Zehr BD, Insel RA. Selective concentration of IgD class-specific antibodies in human milk. Clin Exp Immunol. 1990; 80: 262-267.
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Blais DR, Harrold J, Altosaar I. Killing the messenger in the nick of time: persistence of breastmilk sCD14 in the neonatal gastrointestinal tract. Pediatr Res. 2006; 59: 371-376.
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Andreas NJ, Kampmann B, Mehring Le-Doare K. Human breast milk: A review on its composition and bioactivity. Early Hum Dev. 2015; 91(11): 629-35.
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Bode L. The functional biology of human milk oligosaccharides. Early Hum Dev. 2015; 91(11): 619-22.
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Hassiotou F, Geddes DT. Immune cell-mediated protection of the mammary gland and the infant during breastfeeding. Adv Nutr. 2015; 6(3): 267-75.
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Turfkruyer M, Verhasselt V. Breast milk and its impact on maturation of the neonatal immune system. Curr Opin Infect Dis. 2015; 28(3): 199-206.
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Bourlieu C, Michalski MC. Structure-function relationship of the milk fat globule. Curr Opin Clin Nutr Metab Care. 2015; 18(2): 118-27.
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Rogier EW, Frantz AL, Bruno ME, Wedlund L, Cohen DA, Stromberg AJ, Kaetzel CS. Lessons from mother: Long-term impact of antibodies in breast milk on the gut microbiota and intestinal immune system of breastfed offspring. Gut Microbes. 2014; 5(5): 663-8.
“Your milk appears to switch on a gene in your baby’s body, which produces a hormone called Leptin. This hormone tells your baby when his tummy is full, protecting him against over eating.” and "Your milk contains Leptin, a hormone that regulates appetite by telling our brain when our body has received enough food to generate the energy we need. Moreover, molecules in breastmilk called MicroRNAs influence the expression of our babies’ genes. It appears that these Micro-RNAs switch on the gene in our baby’s body that produces our baby’s own leptin, assisting in our child’s life-long appetite regulation."
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Słyk-Gulewska P., Kondracka A. and Kwaśniewska A. MicroRNA as a new bioactive component in breast milk. Non-coding RNA Research. Noncoding RNA Res. 2023 Dec; 8(4): 520–526.
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Theodore Kelesidis, M.D., Iosif Kelesidis, M.D., Sharon Chou, M.D. and Christos S. Mantzoros, M.D., D.Sc. The Role of Leptin in Human Physiology: Emerging Clinical Applications. Ann Intern Med. 2010 Jan 19; 152(2): 93–100.
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Elena Sinkiewicz-Darol, Iwona Adamczyk, Katarzyna Łubiech, Gabriela Pilarska and Magdalena Twarużek. Leptin in Human Milk - One of the Key Regulators of Nutritional Programming. Molecules. 2022 Jun; 27(11): 3581.
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Palou M, Picó C, Palou A. Leptin as a breast milk component for the prevention of obesity.
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Fields DA, Demerath EW. Relationship of insulin, glucose, leptin, IL-6 and TNF-α in human breast milk with infant growth and body composition. Pediatr Obes. 2012; 7(4): 304-12.
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Savino F, Sardo A, Rossi L, Benetti S, Savino A, Silvestro L. Mother and infant body mass index, breast milk leptin and their serum leptin values. Nutrients 2016; 8: 383.
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Miralles O, Sanchez J, Palou A, Pico C. A physiological role of breast milk leptin in body weight control in developing infants. Obesity 2006; 14: 1371–1377.
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Cannon A, Kakulas F, Hepworth A, Lai C, Hartmann P, Geddes D. The effects of leptin on breastfeeding behaviour. Int. J. Environ. Res. Public Health 2015; 12: 12340–12355.
“Your milk contains Oxytocin, a hormone that induces relaxation, and feelings of well-being in your child and in you.”
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Unvas-Moberg K. Oxytocin linked antistress effects: The relaxation and growth effect. Acta Physiol Scand Supp. 1997; 640: 38-42.
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Groer M, Davis MW. Postpartum stress: current concepts and the possible protective role of breastfeeding. JOGN Nursing. 2002; 31: 411-417.
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Winberg J. Mother and newborn baby: mutual regulation of physiology and behaviour - a selective review. Dev Phychobiol. 2005; 47(3): 217-229.
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Strathearn L. Maternal neglect: oxytocin, dopamine and the neurobiology of attachment. J Neuroendocrinol. 2011; 23(1): 1054-1065.
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Vargas-Martínez F, Schanler RJ, Abrams SA, Hawthorne KM, Landers S, Guzman-Bárcenas J, Muñoz O, Henriksen T, Petersson M, Uvnäs-Moberg K, Jiménez-Estrada I. Oxytocin, a main breastfeeding hormone, prevents hypertension acquired in utero: A therapeutics preview. Biochim Biophys Acta. 2017; 1861(1 Pt A): 3071-3084.
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Jonas W, Woodside B. Physiological mechanisms, behavioral and psychological factors influencing the transfer of milk from mothers to their young. Horm Behav. 2016; 77: 167-81.
"Human milk contains Gangliosides, molecules critical to normal brain development. They help nerves to repair themselves, and cells to communicate with each other. A decrease in the levels of gangliosides in the brain has been reported in Parkinson’s, Alzheimer’s and Huntington’s disease."
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Sipione S, Monyror J, Galleguillos D, Steinberg N and Kadam V. Gangliosides in the Brain: Physiology, Pathophysiology and Therapeutic Applications. 2020; 14: 572965.
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Chowdhury S and Ledeen R. The Key Role of GM1 Ganglioside in Parkinson’s Disease. 2022 Feb; 12(2): 173.
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Rueda R, Cambridge University Press. 2007. The role of dietary gangliosides on immunity and the prevention of infection.
"Human milk contains Docosahexaenoic acid (DHA): An omega-3 fatty acid with an important role in nerve tissue and brain development, particularly with association and short term memory. It also plays a role in the formation of the retina (part of the eye), skin and testicles. The more the mother consumes, through for example certain fish like salmon, or through supplements, the more DHA is found in her milk".
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Juber B. A., Jackson, KH, Johnson KB, Harris WS, and Baack ML. Breast milk DHA levels may increase after informing women: a community-based cohort study from South Dakota USA. Int Breastfeed J. 2016; 12: 7.
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Mahyara Markievicz Mancio Kus-Yamashit, Bonaldi Cano CB, Barros Monteiro VC, Catarino RM. Human Milk: Fast Determination of Docosahexaenoic Acid (DHA), Analytica 2023, 4(1), 54-65
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Horrocks LA, Yeo YK. Health benefits of docosahexaenoic acid (DHA). 1999 Sep; 40 (3) : 211-25.
"The natural terms for us humans to breastfeed until is anywhere between the ages of around 2 and 7+ years old". "Longer term breastfeeding is also associated with reduced risk of diseases for the mother, including breast cancer".
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See our page https://www.human-milk.com/feeding-beyond-babyhood
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Stordal B. Breastfeeding reduces the risk of breast cancer: A call for action in high‐income countries with low rates of breastfeeding. Cancer Med. 2023 Feb; 12(4): 4616–4625.
"Your milk contains macrophages, cells that detect, engulf and destroy harmful pathogens and cells, including tumour cells. They increase in number when your baby is ill." "Your milk contains Phagocytes, a set of immune cells that detect, surround, absorb and destroy harmful molecules and organisms."
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Watanabe S, Alexander M, Misharin AV, G.R. Scott Budinger. The role of macrophages in the resolution of inflammation. J Clin Invest. 2019;129(7):2619–2628.
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Leyva-Cobián F, Clemente J. Department of Immunology, Centro “Ramòn y Cajal”, Carretera de Colmenar Km. 9,100, 28034 Madrid, Spain. Phenotypic characterization and functional activity of human milk macrophages. Immunology Letters, Volume 8, Issue 5, 1984, Pages 249-256.
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Speer CP, Schatz R, Gahr M. Function of breast milk macrophages. Monatsschr Kinderheilkd, 1985 Nov;133(11):913-7.
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Cacho NT, Lawrence RM. Innate Immunity and Breast Milk. Front. Immunol., 29 May 2017, Sec. Microbial Immunology, Volume 8 - 2017.
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Uwe Lendeckel, Simone Venz, and Carmen Wolke. Macrophages: shapes and functions. ChemTexts. 2022; 8(2): 12.
"Your milk contains Leukocytes, white blood cells that locate infections and diseases and defend your babies against parasites, cancer cells, debris, viruses, fungi and even allergens."
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Malgorzata Witkowska-Zimny and Ewa Kaminska-El-Hassan. Cells of human breast milk, Cell Mol Biol Lett. 2017; 22: 11.
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The Journal of Nutrition Field Catherine J. The Immunological Components of Human Milk and Their Effect on Immune Development in Infants, , Volume 135, Issue 1, January 2005.
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Alyssa Tigner; Sherif A. Ibrahim; Ian V. Murray. Histology, White Blood Cell. NIH, November 14, 2022.
"Your baby suckling at your breast is what stimulates the production of your milk. Especially in the first month or so, letting your baby suckle whenever they want to, including at night, is essential to establishing a good supply."
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Infant and Young Child Feeding: Model Chapter for Textbooks for Medical Students and Allied Health Professionals. WHO, Geneva, 2009.
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Breastfeeding at night. La Leche League.